Math model predicts efficacy of heart attack drug treatments – ThePrint – ANIFeed

Washington [US]Jun 18 (ANI): In a recent study, researchers used mice to develop a mathematical model of a heart attack, popularly known as a heart attack.

The research is published in the Journal of Theoretical Biology.

The new model predicts several useful new drug combinations that could one day help treat heart attacks, according to Ohio State University researchers.

Mostly caused by blockages in the coronary arteries — or the blood vessels that supply the heart with blood — these cardiovascular events are experienced by more than 800,000 Americans each year, and about 30 percent eventually die. But even for those who survive, the damage these attacks do to the heart muscles is permanent and can lead to dangerous inflammation in the affected areas of the heart.

Treatment to restore blood flow to these blocked passageways of the heart often involves surgery and medications, or what is known as reperfusion therapy. Nicolae Moise, lead author of the study and a postdoctoral researcher in biomedical engineering at Ohio State, said the study uses mathematical algorithms to assess the efficacy of the drugs used to combat the potentially deadly inflammation many patients experience in the aftermath of an attack.

“Biology and medicine are starting to get more mathematical,” Moise said. “There’s so much data that you have to start integrating it into some kind of framework.” While Moise has worked on other mathematical models of animal hearts, he said the framework described in the current paper is the most detailed diagram of myocardial infarctions in mice ever created.

Represented by a series of differential equations, the model Moise’s team created was created using data from previous animal studies. In medicine, differential equations are often used to chart the growth of diseases.

But this study chose to model how certain immune cells such as myocytes, neutrophils and macrophages — cells necessary for fighting infection and fighting necrosis (toxic damage to the heart) — respond to four different immunomodulatory drugs over a period of time. one month. These drugs are designed to suppress the immune system so that it doesn’t cause as much harmful inflammation in areas of the heart that are damaged.

This study focused on the effectiveness of the drugs one hour after the mice had been treated.

Their findings showed that certain combinations of these drug inhibitors were more efficient at reducing inflammation than others. “In medicine, math and equations can be used to describe these systems,” Moise said. “You just have to observe, and you’ll find rules and a coherent story between them.

“With the therapies we are investigating in our model, we can improve patient outcome even with the best medical care available,” he said.

Depending on their pre-health, it can take six to eight months for a person to recover from a heart attack. The quality of care patients receive in those first few weeks could set the tone for how long their road to recovery will be.

Because Moise’s simulation is purely theoretical, it will not lead to better therapies any time soon. More precise mouse data is needed before their work can be an asset to other scientists, but Moise said he sees the model as a potential tool in the fight against the ravages of heart disease.

“It will be several years before we can actually integrate this kind of approach into actual clinical work,” Moise said. “But what we’re doing is the first step in that direction.” (ANI)

This report is automatically generated by the ANI news service. ThePrint is not responsible for its content.

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