Research finds new understanding of congenital heart disease progression, opens doors to improved treatment options – ThePrint – ANIFeed

Houston [Texas], Jun 22 (ANI): Congenital heart disease (CHD) is a spectrum of heart defects that develop before birth and continue to be the leading cause of infant death. A team of researchers from the Texas Heart Institute, Texas Children’s Hospital and Baylor College of Medicine have uncovered new insights into the mechanisms underlying the progression of CHD.

The findings of the study have been published in the journal Nature.

The first reported single-cell genomics evidence of unique differences in cardiomyocytes and immune systems of CHD patients. Uncovering these important differences and how these diseases progress offers researchers an opening to devise new ways to treat CHD.

While the ultimate outcome of heart failure in CHD is well documented, the underlying cause of declining cardiac function in these patients is still poorly understood. That knowledge gap in understanding has led to roadblocks in developing new therapies that can extend a patient’s life.

To answer these unanswered questions, the Texas Heart Institute and James F. Martin, MD, PhD, of the Texas Heart Institute and Baylor College of Medicine teamed up with Iki Adachi, MD, director of the Mechanical Circulatory Support Program at Texas Children’s and Associate Professor at Baylor College of Medicine, and Diwakar Turaga, MD, PhD, a pediatric cardiac critical care specialist at Texas Children’s Hospital and assistant professor at Baylor College of Medicine, to collect heart and blood samples from CHD patients to profile. The team studied patients with hypoplastic left heart syndrome (HLHS), tetralogy of fallot (TOF), and dilated (DCM), and hypertrophic (HCM) cardiomyopathies undergoing heart surgery.

dr. Martin is an internationally recognized physician-scientist who has made many fundamental contributions to our understanding of cardiac development and disease processes, as well as tissue regeneration.

“Using several exciting new technologies such as single-cell RNA sequencing, we were able to interrogate samples from patients with congenital heart disease at a single-cell level. One of our goals is to improve the natural history of this terrible disease that children says Dr. Martin, director of the Cardiomyocyte Renewal Laboratory at the Texas Heart Institute and Vivian L. Smith Professor in the Division of Integrative Physiology at Baylor College of Medicine. including co-first authors Drs Matthew C. Hill, Zachary A. Kadow and Hali Long are moving towards that goal.”

dr. Turaga is a physician-scientist dedicated to bringing cardiac regenerative medicine to the bedside.

“This is the first step in developing a comprehensive cell atlas of congenital heart disease,” said Dr. Turaga, the physician in Texas Children’s Cardiac Intensive Care Unit as well as an expert in genomics and microscopy. “We are creating a roadmap for therapies that target individual cell types and unique gene pathways in CHD that involve both the heart and the immune system, something that has not been reported before. As the technology matures, it will become the standard of care in treating cancer.” CHD.”

dr. Adachi is a congenital cardiac surgeon at Texas Children’s Hospital who specializes in reconstructive surgical procedures for CHD lesions, including those analyzed in this study.

“What we’ve accomplished with this study is absolutely exciting, but represents just the beginning,” said Dr. Adachi, director of the world’s largest pediatric heart transplant and ventricular aids program. “The collaboration between the Texas Heart Institute’s state-of-the-art lab and Texas Children’s best pediatric heart center certainly has the potential to go further.”

The study’s findings not only provide a new roadmap for developing personalized treatments for CHDs, but also provide the scientific community with a critical source of rare pediatric heart samples that can be used to make further discoveries and deepen our understanding of CHD. (ANI)

This report is automatically generated by the ANI news service. ThePrint is not responsible for its content.

Leave a Comment

Your email address will not be published.