Scientists discover new way of treating solid tumours using Nanoparticles

June 19, 2022 8:04 PM IST

Winston (North Carolina) [US], Jun 19 (ANI): According to a recent study, a group of researchers at Wake Forest University School of Medicine have found a new way to treat solid tumors with the creation of a new nanoparticle. They also found that cancers of the breast, colon, head and neck have tumors that are solid.
In the study, an associate professor of cancer biology at Wake Forest University School of Medicine, Dr. Xin Ming and his team used a nanoparticle to deliver a small molecule called ARL67156 to promote an anti-tumor immune response in mouse models of colon, head and neck, and metastatic breast cancer, resulting in increased survival.
The study was published online in a journal called Science Translational Medicine.
Although immunotherapy has changed cancer treatment, only about 20% of patients respond to treatment.

Speaking of the matter, said Dr. Ming: “Most solid tumors have a poor microenvironment that makes them unresponsive to conventional cancer therapies, including immunotherapy. But this study shows that nanoparticle therapy shows promise.”

According to Ming, levels of an energy-carrying molecule called adenosine triphosphate are high in tumors treated with anticancer therapies and are rapidly broken down into adenosine by a series of enzymes that are highly expressed in the tumors.
The presence of adenosine in the tumor microenvironment may lead to a poor therapeutic response. However, the nanoparticle design allows for the accumulation and release of ARL67156 selectively in solid tumors.
In the study, scientists tested the nanoparticle in several mouse tumor models.
Ming further said, “We found that the nanodrug significantly suppressed tumor growth and resulted in prolonged survival.”
Next, the researchers tested how the nanoparticle worked in combination with an anti-PD-1 antibody, a commonly used immunotherapy. Researchers noted that the treatment worked well and synergistically with anti-PD-1 therapy.
Finally, scientists evaluated nanomedicine in a three-dimensional in vitro model of tumors from patients with colon or breast cancer. Similar effects were seen — increased tumor cell death from an immune response to cancer.
Ming concluded the study: “Our study suggests that there is a potential translation of our nanoparticle therapy for the treatment of human cancers and that it could also increase the effectiveness of existing treatments. These findings warrant further evaluation.” (ANI)

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