US scientists find new way of treating solid cancer tumours, nanomedicine used to draw immune response

Cancer treatment: The scientists also evaluated the nanomedicine in in vitro model of patients with colon and breast cancer. (File)

A group of American scientists has found a new way to treat solid tumors by means of a new nanoparticle. The treatment may work for the cancers of the breast, colon, head and neck, they claimed. dr. Xin Ming, an associate professor of cancer biology at Wake Forest University School of Medicine, said she used a nanoparticle to deliver a molecule called ARL67156 to mice with colon, head and neck cancer and metastatic breast cancer, resulting in increased survival and suppressed tumor growth. The study was published online in a journal called Science Translational Medicine.

dr. Ming said most solid tumors have a poor microenvironment that makes them unresponsive to conventional treatments, including immunotherapy. However, the study shows that nanoparticles can be used to treat these difficult tumors. She added that levels of an energy-carrying molecule called adenosine triphosphate are high in tumors treated with anticancer therapies. They are rapidly broken down into adenosine. This adosine results in a poor response to treatment in cancer patients.

However, the nanodrug suppressed tumor growth and extended the subject’s survival.

The nanoparticle worked in conjunction with an anti-cancer antibody called PD-1, which is used in immunotherapy.

The scientists also evaluated the nanomedicine in in vitro model of patients with colon and breast cancer. It resulted in increased tumor cell death.

She said nanoparticle drugs have potential for treating human cancers and could complement existing treatments.

With input from ANI

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