Vitamin D levels marginally increased in people taking low dose vitamin D3

Despite vitamin D deficiency being common in the Middle East, few studies have attempted to pinpoint its health effects and determine what can be done to combat it.

Therefore, researchers from the University of the United Arab Emirates conducted an RCT to assess whether vitamin D3 and calcium, alone or in combination, have significant health benefits in adults with vitamin D deficiency.

Healthy but low on D?

The researchers recruited 545 “apparently healthy community free-living”adults 18 years of age and older in Al Ain, UAE for the RCT and randomly assigned them to receive tablets containing either 2000 IU oral vitamin D3, 600 mg calcium, a combination of both, or a placebo per day for six months.

The study, conducted over a three-year period, focused on self-rated health and bone turnover markers as primary outcomes and measured the participants’ 25(OH)D levels using their blood and urine samples.

Outcome measures were biochemical variables of metabolic risk factors, bone turnover (biochemical measures of bone metabolism), and muscle and general health. Of the 545 subjects, 277 completed a six-month follow-up after the trial was completed.

The researchers found that 25(OH)D levels “marginally increased” in the two groups that received vitamin D3 alone or in combination with calcium, while a decrease in 25(OH)D levels was seen in those who received vitamin D3 alone. had received the calcium supplement or a placebo.

According to subgroup analysis, parathyroid hormone (PTH) concentration decreased and the calcium-creatinine ratio increased significantly in those who took a combination of vitamin D and calcium, compared to those who took vitamin D or calcium alone, while an increase in both was seen in the placebo group.

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